Chemical Biology

The field of chemical biology lies at the interface of chemistry and biology. It uses chemistry, chemical principles, and notably molecules to study and solve important issues in biology. The course will focus on chemical and biological syntheses and behaviours of relevant molecules for chemical biology, primarily carbohydrates, peptides and nucleic acids, as well as their uses in addressing biological questions. Bio-orthogonal reactions and the use of the compounds derivatized as chemical probes will also be discussed. This course will also have an emphasis on critical reading of recent literature and presentation on this to the group.

On completion of this course, the student will be able to:

• Demonstrate an appreciation of the chemical nature of biological systems and the biological behaviour of chemicals.

• Demonstrate an understanding of the chemical and biological synthesis of biomolecules (nucleic acids, peptides, and carbohydrates).

• Demonstrate an understanding of the three dimensional structure of biomolecules, and how this structure interacts with function.

• Demonstrate an understanding of recent developments in selection-based discovery methods, bio-orthogonal chemistry, and chemical probes of biological systems

• Critically read research articles in the literature, and present this information in a manner accessible to peers.

Participants should have a solid foundation in organic chemistry and biochemistry. This course will assume reasonable knowledge of chemical functional groups, reactivity, and mechanisms. A first year chemistry course level is required, such as FA-CPS104 or SK-B1BIOC or equivalent, while aspects of a second year chemistry course such as FA-CPS-311 or SK-BORC13 would be beneficial. If you are uncertain regarding the adequacy of your chemistry level, please contact the coordinator. A first year bio

• Book Introduction to Bioorganic Chemistry and Chemical Biology. D. van Vranken and G. Weiss. Garland Science 2013. ISBN 978-0-8153-4214-4