Nutrition and the Ageing Body

The world is facing an unprecedented increase in population ageing. In the Netherlands, the rate of greying will even double in the next decades (CBS), causing increased pressure on healthcare systems. To bend this trend into a more favourable direction, knowledge is needed of the interplay between nutrition, other lifestyle factors and the ageing processes occurring throughout the human body.

In this course, students embark on a journey through the human body to encounter a sequence of biological events starting early in life (ageing) with a considerable inter-individual variation. First, a deep dive into biological ageing will be given, with many examples on how nutrition can be used to target the ageing processes themselves. Then, intermediate stops will be made at organs and tissues where both the ageing process and nutrition have a high impact. Here, optimal nutrition can make a difference in ageing healthfully and in preserving functionality. Stops include the gut, the circulation, the bone with its connective tissue, the skin, the brain and the muscle. Due attention will be given to the cross-talk between organs and tissues, to capture e.g, the gut-brain, the gut-muscle, the brain-bone axis and to nutrient interactions. This course underlines that optimal nutrition is of major importance for healthy ageing and the quality of life of older adults.

• Recognise the key changes that occur during ageing at the level of the whole body, the gastrointestinal system, kidney and heart, the muscle, bone and joints, the skin and the brain

• Explain the major determinants of the ageing process and the interindividual differences

• Discuss the role that nutrition plays in the ageing process, acknowledging the cross-talk between organs and tissues

• Explain the impact of the key changes that occur during ageing on nutrient requirements, acknowledging interactions between nutrients

• Argue nutrition and lifestyle interventions that attenuate the causes and consequences of the ageing process

• Form opinions on integrated nutritional approaches and discuss them with physiologists, clinicians, health professionals and older adults

• Hypothesise how nutrients can benefit healthy ageing on whole body and organ level

• Written test with open and closed questions (50%) Grades are valid for the academic year in which they are obtained, plus the following academic year.
• Assignment portfolio (40%) Report part of the Portfolio, may be adjusted based on individual contribution. Group size 5-7. Grades are valid for the academic year in which they are obtained, plus the following academic year. In case of failed, students can hand in a revised version at the next re-sit period.
• Assignment oral presentation (10%) Presentation of the Portfolio, may be adjusted based on individual contribution. Mandatory presence during the session, otherwise replacing essay assignment.Group size 5-7. Grades are valid for the academic year in which they are obtained, plus the following academic year. In case of failed, students can hand in a revised version at the next re-sit period.
• Performance (0%) Providing peer-feedback is required for passing the course.

Bachelor level knowledge on Nutrition Science or equivalent (e.g. Biomedical Sciences), including the micro- and macronutrients, plus at master level HAP30306 (Nutritional Physiology).

• Kick off references: Partridge: Facing up the global challenges of ageing (Nature 2018;561:45-44); Rattan: Biogerontology: research status, challenges and opportunities. (Acta Biomed. 2018 Jun 7;89(2):291-301. doi: 10.23750/abm.v89i2.7403.) Kick off Neflix documentary: Don't Die: The man who wants to live forever. Brightspace for further literature, and handouts of the lectures