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The full range of minors offered by the LDE institutions for the academic year 2025-2026 will be published on eduXchange at the beginning of March.
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  2. Advanced Biomolecular NMR

Advanced Biomolecular NMR

SK-MCABNMR

About this course

Description of content

		The nuclear spin is the ultimate spy. Nuclear magnetic resonance exploits the spin’s special properties to study molecular structure and dynamics in a non-invasive way. Key herein is control over the state of the spin. But how do you exercise such control? How do you exploit such control to extract information on the molecule’s structure and motions?  
		   
		This course will cover the principles of both solid and solution-state NMR and its application to biomolecules. Emphasis will be on a conceptual and practical understanding of NMR theory and its application to current challenges in structural biology.  
		   
		The course will consist of lectures, exercises, a paper presentation, a computer practical and a practical at the NMR machine (depending on the number of students). The paper presentation will count 20% and the exam 80% towards the final grade.  
		   
		  
		**Course Programme**   
		  
		The course runs over four weeks, with most lectures and practicals in the first two weeks. There are four full days on solution-NMR, and four full days on solid-state NMR. Each day consists of interactive lectures, exercise sessions and computer practicals or demonstrations. In between lecture days there are self-study days to help you digest the course material. In the last week you present a scientific paper and have the exam.  
		  
		   
		**Literature/study material used** :  
		  
		  
		Recommended book for further in depth reading:  
		   
		·         J. Keeler, Understanding NMR Spectroscopy, 2nd edition, Wiley, 2006.  
		   
		Handouts of the lectures, material for the computer practicals and exercise session will be provided in class.  
		   
		The students need to bring their own laptop for the practicals.  
		   
		**Registration** :  
		Osiris Student  
		**Mandatory for students in Master’s programme** : NO.  
		**Optional for students in other Master’s programmes GS-LS** : YES.

Learning outcomes

Leerdoelen voor de cursus
At the end of the course, students should have a profound understanding of:
· NMR and its applications in life sciences;
· the range of samples that can be studies by either solution or solid-state NMR;
· the relation between NMR parameters and molecular structure and dynamics.

		After completing the course the student is able to:  
		·         describe and identify the different elements of an NMR experiment (solution and solid-state);  
		·         describe the underlying concept of the product operator formalism;  
		·         use the product operator formalism to analyze solution-state NMR experiments;  
		·         describe how high-resolution spectra of solids can be obtained;  
		·         describe the diverse methods of sensitivity improvement;

Enrolment details

Do you study at Eindhoven University of Technology (TU/e) or Wageningen University and Research (WUR)? You can enrol via eduXchange.nl

Prior knowledge

You must meet the following requirements

  • Assigned study entrance permit for the master

Resources

  • Book J. Keeler, Understanding NMR Spectroscopy, 2nd edition, Wiley, 2006
  • Handouts
  • Software Geen software nodig
  • Book NMR: The Toolkit, P.J. Hore, J.A. Jones and S. Wimperis. Oxford Chemistry Primers, a primer (Spin Mechanics, NMR Department)

Additional information

  • Credits
    ECTS 4.5
  • Level
    master
  • Selection course
    No
If anything remains unclear, please check the FAQ of Utrecht University.

Offering(s)

  • Start date

    21 April 2025

    • Ends
      4 July 2025
    • Term *
      Period 4
    • Location
      Utrecht
    • Instruction language
      English
    • Time info
      Monday 09:00 - 09:45, Monday 09:00 - 10:45, Monday 09:00 - 11:45, Monday 09:00 - 12:00, Monday 09:00 - 12:45, Monday 09:00 - 15:00, Monday 09:00 - 17:00, Monday 10:00 - 10:45, Monday 10:00 - 12:45, Monday 10:00 - 16:00, Monday 11:00 - 11:45, Monday 11:00 - 12:45, Monday 11:00 - 15:00, Monday 11:00 - 17:00, Monday 12:00 - 12:45, Monday 13:15 - 14:00, Monday 13:15 - 15:00, Monday 13:15 - 16:00, Monday 13:15 - 17:00, Monday 13:15 - 19:00, Monday 14:15 - 15:00, Monday 14:15 - 17:00, Monday 15:15 - 16:00, Monday 15:15 - 17:00, Monday 15:15 - 18:00, Monday 15:15 - 19:00, Monday 16:15 - 17:00, Monday 16:15 - 19:00, Monday 17:15 - 18:00, Monday 17:15 - 19:00, Monday 18:15 - 19:00, Tuesday 09:00 - 09:45, Tuesday 09:00 - 10:45, Tuesday 09:00 - 12:00, Tuesday 09:00 - 12:45, Tuesday 09:00 - 15:00, Tuesday 09:00 - 17:00, Tuesday 10:00 - 10:45, Tuesday 10:00 - 12:45, Tuesday 10:00 - 16:00, Tuesday 11:00 - 11:45, Tuesday 11:00 - 12:45, Tuesday 11:00 - 15:00, Tuesday 11:00 - 17:00, Tuesday 12:00 - 12:45, Tuesday 13:15 - 14:00, Tuesday 13:15 - 15:00, Tuesday 13:15 - 16:00, Tuesday 13:15 - 17:00, Tuesday 13:15 - 19:00, Tuesday 14:15 - 15:00, Tuesday 14:15 - 17:00, Tuesday 15:15 - 16:00, Tuesday 15:15 - 17:00, Tuesday 15:15 - 18:00, Tuesday 15:15 - 19:00, Tuesday 16:15 - 17:00, Tuesday 16:15 - 19:00, Tuesday 17:15 - 18:00, Tuesday 17:15 - 19:00, Tuesday 18:15 - 19:00, Wednesday 09:00 - 09:45, Wednesday 09:00 - 10:45, Wednesday 09:00 - 12:00, Wednesday 09:00 - 12:00, Wednesday 09:00 - 12:45, Wednesday 09:00 - 15:00, Wednesday 09:00 - 17:00, Wednesday 10:00 - 10:45, Wednesday 10:00 - 12:45, Wednesday 10:00 - 16:00, Wednesday 11:00 - 11:45, Wednesday 11:00 - 12:45, Wednesday 11:00 - 15:00, Wednesday 11:00 - 17:00, Wednesday 12:00 - 12:45, Wednesday 13:15 - 14:00, Wednesday 13:15 - 15:00, Wednesday 13:15 - 16:00, Wednesday 13:15 - 17:00, Wednesday 13:15 - 19:00, Wednesday 14:15 - 15:00, Wednesday 14:15 - 17:00, Wednesday 15:15 - 16:00, Wednesday 15:15 - 17:00, Wednesday 15:15 - 18:00, Wednesday 15:15 - 19:00, Wednesday 16:15 - 17:00, Wednesday 16:15 - 19:00, Wednesday 17:15 - 18:00, Wednesday 17:15 - 19:00, Wednesday 18:00 - 21:00, Wednesday 18:15 - 19:00, Thursday 09:00 - 09:45, Thursday 09:00 - 10:45, Thursday 09:00 - 12:00, Thursday 09:00 - 12:45, Thursday 09:00 - 15:00, Thursday 09:00 - 17:00, Thursday 10:00 - 10:45, Thursday 10:00 - 12:45, Thursday 10:00 - 16:00, Thursday 11:00 - 11:45, Thursday 11:00 - 12:45, Thursday 11:00 - 15:00, Thursday 11:00 - 17:00, Thursday 12:00 - 12:45, Thursday 13:15 - 14:00, Thursday 13:15 - 15:00, Thursday 13:15 - 16:00, Thursday 13:15 - 17:00, Thursday 13:15 - 19:00, Thursday 14:15 - 15:00, Thursday 14:15 - 17:00, Thursday 15:15 - 16:00, Thursday 15:15 - 17:00, Thursday 15:15 - 18:00, Thursday 15:15 - 19:00, Thursday 16:15 - 17:00, Thursday 16:15 - 19:00, Thursday 17:15 - 18:00, Thursday 17:15 - 19:00, Thursday 18:15 - 19:00, Friday 09:00 - 09:45, Friday 09:00 - 10:45, Friday 09:00 - 11:45, Friday 09:00 - 12:00, Friday 09:00 - 12:45, Friday 09:00 - 15:00, Friday 09:00 - 17:00, Friday 10:00 - 10:45, Friday 10:00 - 12:45, Friday 10:00 - 16:00, Friday 11:00 - 11:45, Friday 11:00 - 12:45, Friday 11:00 - 15:00, Friday 11:00 - 17:00, Friday 12:00 - 12:45, Friday 13:15 - 14:00, Friday 13:15 - 15:00, Friday 13:15 - 16:00, Friday 13:15 - 17:00, Friday 14:15 - 15:00, Friday 14:15 - 17:00, Friday 15:15 - 16:00, Friday 15:15 - 17:00, Friday 15:15 - 19:00, Friday 16:15 - 17:00, Friday 17:15 - 19:00
    Enrolment period closed

  • Start date

    20 April 2026

    • Ends
      3 July 2026
    • Term *
      Period 4
    • Location
      Utrecht
    • Instruction language
      English
    • Time info
      Monday 09:00 - 09:45, Monday 09:00 - 10:45, Monday 09:00 - 11:45, Monday 09:00 - 12:00, Monday 09:00 - 12:45, Monday 09:00 - 15:00, Monday 09:00 - 17:00, Monday 10:00 - 10:45, Monday 10:00 - 12:45, Monday 10:00 - 16:00, Monday 11:00 - 11:45, Monday 11:00 - 12:45, Monday 11:00 - 15:00, Monday 11:00 - 17:00, Monday 12:00 - 12:45, Monday 13:15 - 14:00, Monday 13:15 - 15:00, Monday 13:15 - 16:00, Monday 13:15 - 17:00, Monday 13:15 - 19:00, Monday 14:15 - 15:00, Monday 14:15 - 17:00, Monday 15:15 - 16:00, Monday 15:15 - 17:00, Monday 15:15 - 18:00, Monday 15:15 - 19:00, Monday 16:15 - 17:00, Monday 16:15 - 19:00, Monday 17:15 - 18:00, Monday 17:15 - 19:00, Monday 18:15 - 19:00, Tuesday 09:00 - 09:45, Tuesday 09:00 - 10:45, Tuesday 09:00 - 12:00, Tuesday 09:00 - 12:45, Tuesday 09:00 - 15:00, Tuesday 09:00 - 17:00, Tuesday 10:00 - 10:45, Tuesday 10:00 - 12:45, Tuesday 10:00 - 16:00, Tuesday 11:00 - 11:45, Tuesday 11:00 - 12:45, Tuesday 11:00 - 15:00, Tuesday 11:00 - 17:00, Tuesday 12:00 - 12:45, Tuesday 13:15 - 14:00, Tuesday 13:15 - 15:00, Tuesday 13:15 - 16:00, Tuesday 13:15 - 17:00, Tuesday 13:15 - 19:00, Tuesday 14:15 - 15:00, Tuesday 14:15 - 17:00, Tuesday 15:15 - 16:00, Tuesday 15:15 - 17:00, Tuesday 15:15 - 18:00, Tuesday 15:15 - 19:00, Tuesday 16:15 - 17:00, Tuesday 16:15 - 19:00, Tuesday 17:15 - 18:00, Tuesday 17:15 - 19:00, Tuesday 18:15 - 19:00, Wednesday 09:00 - 09:45, Wednesday 09:00 - 10:45, Wednesday 09:00 - 12:00, Wednesday 09:00 - 12:00, Wednesday 09:00 - 12:45, Wednesday 09:00 - 15:00, Wednesday 09:00 - 17:00, Wednesday 10:00 - 10:45, Wednesday 10:00 - 12:45, Wednesday 10:00 - 16:00, Wednesday 11:00 - 11:45, Wednesday 11:00 - 12:45, Wednesday 11:00 - 15:00, Wednesday 11:00 - 17:00, Wednesday 12:00 - 12:45, Wednesday 13:15 - 14:00, Wednesday 13:15 - 15:00, Wednesday 13:15 - 16:00, Wednesday 13:15 - 17:00, Wednesday 13:15 - 19:00, Wednesday 14:15 - 15:00, Wednesday 14:15 - 17:00, Wednesday 15:15 - 16:00, Wednesday 15:15 - 17:00, Wednesday 15:15 - 18:00, Wednesday 15:15 - 19:00, Wednesday 16:15 - 17:00, Wednesday 16:15 - 19:00, Wednesday 17:15 - 18:00, Wednesday 17:15 - 19:00, Wednesday 18:00 - 21:00, Wednesday 18:15 - 19:00, Thursday 09:00 - 09:45, Thursday 09:00 - 10:45, Thursday 09:00 - 12:00, Thursday 09:00 - 12:45, Thursday 09:00 - 15:00, Thursday 09:00 - 17:00, Thursday 10:00 - 10:45, Thursday 10:00 - 12:45, Thursday 10:00 - 16:00, Thursday 11:00 - 11:45, Thursday 11:00 - 12:45, Thursday 11:00 - 15:00, Thursday 11:00 - 17:00, Thursday 12:00 - 12:45, Thursday 13:15 - 14:00, Thursday 13:15 - 15:00, Thursday 13:15 - 16:00, Thursday 13:15 - 17:00, Thursday 13:15 - 19:00, Thursday 14:15 - 15:00, Thursday 14:15 - 17:00, Thursday 15:15 - 16:00, Thursday 15:15 - 17:00, Thursday 15:15 - 18:00, Thursday 15:15 - 19:00, Thursday 16:15 - 17:00, Thursday 16:15 - 19:00, Thursday 17:15 - 18:00, Thursday 17:15 - 19:00, Thursday 18:15 - 19:00, Friday 09:00 - 09:45, Friday 09:00 - 10:45, Friday 09:00 - 11:45, Friday 09:00 - 12:00, Friday 09:00 - 12:45, Friday 09:00 - 15:00, Friday 09:00 - 17:00, Friday 10:00 - 10:45, Friday 10:00 - 12:45, Friday 10:00 - 16:00, Friday 11:00 - 11:45, Friday 11:00 - 12:45, Friday 11:00 - 15:00, Friday 11:00 - 17:00, Friday 12:00 - 12:45, Friday 13:15 - 14:00, Friday 13:15 - 15:00, Friday 13:15 - 16:00, Friday 13:15 - 17:00, Friday 14:15 - 15:00, Friday 14:15 - 17:00, Friday 15:15 - 16:00, Friday 15:15 - 17:00, Friday 15:15 - 19:00, Friday 16:15 - 17:00, Friday 17:15 - 19:00
    Enrolment period not yet defined
* View scheduling details of Utrecht University
For guests registration, this course is handled by Utrecht University