Introduction to regenerative medicine and technology

The course will consist of a program of 10 weeks, divided in 2 blocks (A and B). This course provides the students with a broad overview and background in ‘Regenerative Medicine and Technology’. Lectures and group projects will prepare the students for research using tissue regeneration technologies.The lay-out of the ten weeks will be as follows:Week 1: UU Introduction week including specific Regenerative Medicine and Technology intro

Block A: Weeks 2-7: Parallel classes with focus on molecular cell biology (for students with biotechnology background) and regenerative engineering (for students with biomedical background). Journal clubs and expert lectures on Regenerative Medicine and Technology research topics. Writing an opinion article. Concluded with a test at the end of week 7.

Block B: Weeks 8-10: Writing of research proposal (in groups) and closing session with poster presentation.Contact hours will be equally distributed between Eindhoven and Utrecht. In block A, daily classes in the form of lectures, peer teaching, discussions and quizzes will cover basic regenerative medicine and technology topics from textbooks, e.g. organogenesis, embryogenesis, biomechanics and imaging techniques (for a more detailed description the student is referred to the block book). Self-study/preparation time for the journal clubs (on literature provided by the experts on their topic) and expert lectures. Journal clubs will be presented by groups, each group will be responsible for 1 journal club. In addition to this, groups will write a short opinion article on an ethical issue in RM.
The group project in Block B consists of writing a research proposal that is aimed at the regeneration of a specific tissue (e.g. heart valve, cartilage). Information from block A will be incorporated into the research proposals under weekly supervision of a tissue specific expert so that student can directly apply the knowledge obtained. At the end of the block, the groups will present their proposal to representatives of the Regenerative Medicine and Technology program committee and each other in the form of a poster session.

After following this course, the student:

• is able to describe the development, tissue maintenance and pathology of specialized tissues and appreciate the rationale for regenerative medicine strategies
• understands and can apply cell engineering techniques and (environmental) signaling to improve cellular behavior in regenerative medicine
• is able to describe cell matrix interactions and the mechanical properties of specialized tissues and apply these requisites to design a biomaterial to answer a specific research questions in the field of regenerative medicine and technology
• can describe and distinguish between different in vitro, in vivo and ex vivo research models and techniques and determine which models/techniques can be used to answer a specific research or clinical diagnostic question
• can develop a strategy from bench-to-bed to answer a specific research question
• can describe the ethics of first-in-human (regenerative medicine) trials, for example with regard to the use of (stem)cells, biobanking, participant selection and trial design
• knows the basics of regenerative medicine and technology. The student is acquainted with topics from the broad spectrum that makes up regenerative medicine and technology,
• knows which challenges and approaches dominate frontier research of generation of various tissues

Je moet voldoen aan de volgende eisen

• Bachelor of Science (BSc) afgerond

• Block book
• Principles of Regenerative Medicine
• Materiaal wordt later verstrekt Handouts, including references to books or literature, will be provided by the lecturers.
• Biomechanics: concepts and computation