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General Toxicology

TOX20303

About this course

Introductory course on basic principles in toxicology, organ-specific toxic effects and risk assessment.

Learning outcomes

After successful completion of this course students are expected to be able to:

  • summarize important generalized toxicological (biochemical) mechanisms underlying toxic responses following exposure to toxic chemicals;
  • interpret the consequences of physiological processes on toxic responses in the human body;
  • apply some important mechanisms (modes of action) of toxic chemicals that underlie the adverse effects observed to important toxic chemicals in food and the environment;
  • Argue how non-laboratory animal data can be used in the toxicological risk assessment of chemicals;
  • recall what type of data is required by regulatory bodies for the safety assessment of chemicals;
  • design and execute a comprehensive toxicological concentration-response experiment and critically report and discus the results;
  • apply the basic principles of risk assessment of chemicals in food and the environment.

Teaching method and examination

The assessment will be based on the following outcomes:
Exam:
In this written exam the theoretical base of general toxicology will be assessed. The written exam contains closed and some open questions. It contributes for 80% for the overall grade, the final mark of the exam has to be at least 5.50. The exam is based on the content of the lectures, the syllabus/reader that is available on Brightspace, as well as on content of the clips on Brightspace.

Practical:
You have to write brief reports, based on the obtained results. These reports will be assessed. The overall final mark of the practical has to be at least 5.50 (and contributes 20% to the final grade). The theoretical exam may contain questions related to the experiments.The practical assignment includes a virtual practical on the Zebrafish embryo test. The theoretical exam may contain questions related to the virtual practicalThe risk assessment tutorial itself will not be graded, but the theoretical exam may contain questions related to the content in the tutorial.

Required prior knowledge

Mandatory Knowledge:
ZSS06100 Laboratory Safety

Link to more information

If anything remains unclear, please check the FAQ of Wageningen University.

Offering(s)

  • Start date

    11 maart 2024

    • Ends
      3 mei 2024
    • Term *
      Period 5
    • Location
    • Instruction language
      English
    Enrolment period closed
These offerings are valid for students of Utrecht University